ClusterSingleton guaranteed to be single threaded?

If I create a cluster singleton like below

 ActorSystem system = ActorSystem.create("ClusterSystem", config);
      ClusterSingletonManagerSettings settings = ClusterSingletonManagerSettings.create(system)
          .withRole("compute");
      system.actorOf(ClusterSingletonManager.props(
          Props.create(StatsService.class), PoisonPill.getInstance(), settings),
          "statsService");

Is it guaranteed that only one copy of the StatsService actor exists and will be single threaded?

There will only be one instance, but it will not be single threaded, however, it will only ever process a message on one thread at a time, and can safely keep mutable state - just like any actor.

If you need to dedicate a thread to the singleton, for example you have some library that needs the thread to be the same at all times for some reason, you will need to use a pinned dispatcher for it.

If the cluster singleton (like stats service in the example above), is holding an instance to a cache store

Jedis jedis = new Jedis("hostname.redislabs.com", 6379);

Is it safer instead to use a connection pool or it doesn’t matter?

JedisPool pool = new JedisPool(new JedisPoolConfig(), "localhost");

It should be enough to use one connection since the actor will process one message at a time, sequentially.